The team of Juan Montoya has integrated a range of factors into a single statistical model to study the genesis of genetic diversity within a typical Amazonian species. This new approach, adaptable to any species, enables to assess the impact of present and future human large-scale alterations. The study was published on December 20, 2017 in PLoS ONE.
A study led by Sandra Citi shows that the proteins Zonula Occludens-1 and -2, which contribute to the tightness of the epithelium, perceive mechanical forces and activate different cellular responses accordingly. This novel process was unveiled on November 30, 2017 in the journal Current Biology.
This health tech company has been named on the MIT Technology Review 2017 list of ‘50 Smartest Companies’, which identifies companies creating new opportunities by combining important technologies and business savvy.
Our Section congratulates Jurgi Camblong, who has done his PhD and post-doc in the lab of Françoise Stutz.
BiOutils et TheScienceBreaker proposent aux enseignants un mini-magazine innovant pour une immersion au cœur de l’actualité scientifique. Composé d’articles vulgarisés et d’une activité pratique permettant de mieux comprendre la démarche scientifique sous-jacente, Break’d ! sera proposé tous les deux mois.
Des webinaires permettant aux élèves d’interagir directement avec un chercheur sont aussi prévus.
The body of some catfish is completely covered with teeth that regenerate. Carlos Rivera-Rivera and Juan Montoya-Burgos discovered that these extra-oral teeth always grown on a bone, regardless of its type, which suggests a role for bone in the induction of dental tissue. These results, published on October 18, 2017 in Proceedings of the Royal Society, help to elucidate the mechanisms allowing the formation and regeneration of teeth in all vertebrates.
The team of Denis Duboule has discovered that specific mutations in the Hoxd3 gene induce defective breast milk assimilation and important, often lethal, growth retardation in newborn mice. This work, published on October 16, 2017 in PNAS, suggests that this genetic defect probably contributes to certain types of intestinal insufficiency in premature infants.
The group of Alicia Sanchez-Mazas identified two HLA-B alleles as candidates to Plasmodium falciparum malaria protection in Africa. Their study, published on October 16th, 2017 in Molecular Ecology, suggested that these alleles, which share close peptide-binding profiles, became beneficial at the onset of this disease. Pathogen-driven selection in the form of soft selective sweep thus likely contributed to shape the HLA-B genetic landscape of Africa.
TORC1 is an enzyme complex that controls the normal growth of our cells; but, when too active, it can promote diseases such as cancer. A study led by the team of Robbie Loewith and published on October 4, 2017 in Nature describes how sugar regulates the activity of TORC1, through a surprising mechanism.