A mechanism for the transformation of colon polyps is identified

In order to better determine the origin and the sequence of events responsible for the onset of colon cancer, the team led by Thanos Halazonetis has sequenced the DNA of biopsied tissue from colon polyps. The results show that in this type of lesion, the rate of progression from a precancerous state to the tumor stage accelerates over time.The study, published December 1, 2012 in Cancer Research, also designates mutations in three specific genes as being the likely initiators of the progression towards malignancy.

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