A gene could prevent Parkinson’s disease

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Parkinson’s disease is a neurodegenerative disorder characterized by the destruction of a specific population of neurons: the dopaminergic neurons. The degeneration of these neurons prevents the transmission of signals controlling specific muscle movements and leads to tremors, involuntary muscle contractions or balance problems characteristic of this pathology. Emi Nagoshi‘s group form the Genetics & Evolution’s Dpt has investigated the destruction of these dopaminergic neurons using the fruit fly as study model. The scientists identified a key protein in flies, and also in mice, which plays a protective role against this disease and could be a new therapeutic target.

This article was published in the journal Nature Communications on March 17, 2022.

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