A molecular magnet controlling DNA replication

The team of David Shore has shown how telomeres control the initiation of DNA replication genome-wide. The study, published on April 24, 2018 in Cell Reports, reveals that a telomere-binding protein called Rif1 is sequestered at telomeres, limiting its repressive effect on origins of DNA replication to regions near the ends of chromosomes. This may allow chromosomes ends to act as nurseries for genome evolution.