‘When we analyzed the genes expressed over time by different cells in these tiny gastruloids, we found the pattern was remarkably similar to that of the posterior part of a mouse embryo’, explains Denis Duboule.
In collaboration with the University of Cambridge and the EPFL, the group of Denis Duboule has developed murine artificial pseudo-embryos capable of forming the three major axes of the body. These ‘gastruloids’, detailed on October 3, 2018 in Nature, possess a remarkable potential for the study of the early stages of normal or pathological embryonic development.
With just a molecular nudge, aggregates of embryonic stem cells take shape as a “gastruloid,” bearing the genetic hallmarks and spatial organization of early development. The team of Denis Duboule has participated in this study, in collaboration with the University of Cambridge and the EPFL.
The team of Michel Milinkovitch has discovered that elephants regulate their body heat through their skin, which cracks into deep crevices, absorbing a maximum water. These results were published on October 2, 2018 in Nature Communications.
Video showing in detail the skin structure of the African elephant
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