Of multiple-horned goats and sheep


Bovidae sometimes display supernumerary horns. For instance, local breeds of sheep genetically selected by generations of breeders, are known for their multiple horns, a condition referred to as ‘polyceraty’. It also happens, particularly in the Alps, that goats spontaneously develop an additional pair of horns. While the genetic causes of this morphological curiosity have long remained unknown, it seems that this mystery has now found its solution. Indeed, a genomic study of many such mutant animals, carried out by the French National Institute for Agricultural and Environmental Research (INRAE) and the union of breeding cooperatives ALLICE together with Pr Denis Duboule’s group, in collaboration with the EPFL and several other research centers distributed over four continents, reveals that all the four-horned goats and sheep analyzed carry a mutations affecting the same gene: HOXD1.

The article was published in the journal Molecular Biology and Evolution on February 16, 2021.

Press release

This study is also covered by other media :

Le mystère du bouc à quatre cornes levé Tribune de Genève, 17.02.2021

Mystère génétique résolu 20 Minutes Genève, 17.02.2021

Le mystère des chèvres et moutons à quatre… swissinfo.ch/fr / swissinfo FR, 17.02.2021

A constitutively monomeric UVR8 photoreceptor confers enhanced UV-B photomorphogenesis


Coping with UV-B is crucial for plant survival in sunlight. The UV-B photoreceptor UVR8 regulates gene expression associated with photomorphogenesis, acclimation and UV-B stress tolerance. UV-B photon reception by UVR8 homodimers results in monomerization, followed by interaction with the key signaling protein COP1. Roman Ulm’s group, in collaboration with Michael Hothorn‘s group, has discovered a UV-B hypersensitive UVR8 photoreceptor (UVR8G101S) that confers strongly enhanced UV-B tolerance and generated a novel UVR8 variant based on the underlying mutation that shows extremely enhanced constitutive signaling activity. These findings provide key mechanistic insight into how plants respond and acclimate to UV-B radiation.

This article was published in PNAS on February 9, 2021.

Discovery of a phosphate sensing and signaling pathway in plants


Cells require sufficient amounts of the element phosphorus to build their membranes and to store and copy genetic information. Phosphorus is taken up by cells in the form of inorganic phosphate, an important signaling molecule and energy currency. While we take up sufficient amounts of phosphate with our diet, plants have to mobilize and take up phosphate from the soil, where it is poorly bioavailable. Phosphate thus limits the growth of plants, and phosphate fertilizers have to be used to maximize crop yields. How plant cells measure cellular phosphate levels and how they decide if and when to take up more phosphate is poorly understood.

The Hothorn lab has previously shown that phosphate-rich inositol pyrophosphates are nutrient messengers in plants and identified SPX domains as their cellular receptors. In a new report, the Hothorn, Hiller (Biozentrum Basel) and Fiedler (FMP Berlin) labs now report that inositol pyrophosphates control the activity of the transcription factor PHOSPHATE STARVATION RESPONSE 1 (PHR1). When there is enough phosphate in the cell, inositol pyrophosphates bind to the SPX receptor which in turn binds to PHR1, keeping it in a isolated form unable to active gene expression. When phosphate becomes limiting, inositol pyrophosphates are less abundant, the SPX – PHR1 complex dissociates and the free transcription factor can interact with itself and activate the expression of genes involved in phosphate uptake. This signaling mechanism may now be exploited towards the development of phosphate starvation tolerant crops that would require less phosphate fertilizer.

The article was published in Nature Communications, on January 15th 2021.


The wings of a “genetic bird” protect us against viruses


Modelling of HLA-peptide bindings forming the two wings of a bird in flight.

Do populations from different geographic regions have the same potential for defending themselves against pathogens and against viruses in particular? An analysis of human genomes, especially the HLA genes responsible for the so-called “adaptive” immune system, provide some possible answers to this question. These genes, which vary enormously between individuals, code for molecules capable of recognising the different viruses so they can trigger the appropriate immune response.

Alicia Sanchez-Mazas‘s group, partnering with Cambridge University, has identified the HLA variants that bind to families of viruses most effectively. Their study show that, in spite of the great heterogeneity of HLA variants in individuals, all populations benefit from an equivalent potential when it comes to virus protection.

The article was published in the journal Molecular Biology and Evolution, on December 15th, 2020.

Press release from UNIGE.